Deep in Salazar’s decrepit castle, a grotesque abomination awaits-Ramon Salazar himself, fused with his own twisted creation, ready to test your every move.
Throughout this walkthrough, we’re not going to mention every item that anyone (or anything) you shoot drops – if you kill something, look for a loot drop.
Also, there’s a little randomness to the contents of crates based on your inventory and weapons, so you probably won’t find the exact same things listed below. The crates and barrels themselves will always be in the same locations, though. And all other items – keys, collectibles, and resources not found in crates – should be the same.
Prepare for the Ramon Salazar boss fight
Stock up on shotgun shells, rifle ammo, and healing items before entering the throne room, as Salazar’s weak point is the eye in his mutated form. Equip a high-damage handgun or magnum for precise shots once he exposes his core, and bring plenty of grenades to punish him when he pauses or moves along the walls. Upgrade your preferred weapons beforehand, especially power and reload speed, and craft extra ammo so you are not forced to scavenge mid-fight.
You’re about to take on a boss fight against Ramon Salazar. It’s a pretty frenetic fight, but it’s not really complicated – shoot him a bunch until he falls down. The key is dealing damage fast against a moving target while you’re also moving, and that means you want weapons with a good rate of fire.
Using a weapon like the Red9 is just going to make this fight more frustrating and drawn out. The Stingray rifle will. too, since Ramon will be moving so fast.
If you have the 22 spinels, trade them for the Matilda handgun and Matilda Stock at the Merchant. When you put them together, it gets you a three-round burst with descent damage – and it uses handgun ammo, which is both cheaper to make and more abundant than rifle ammo.
If you have a few extra rifle bullets to burn, the CQBR Assault Rifle we picked up back in Chapter 10 is great too.
Beyond that, the Striker shotgun and the Broken Butterfly magnum are good for when Ramon gets in close to you
Defeat Ramon Salazar // Ancient Chantry
Ramon Salazar awaits Leon in the Ancient Chantry, twisted by his union with a monstrous parasite. The battle demands constant movement-avoid his acidic projectiles while targeting the exposed weak spot on his mutated form. Use the arena’s ledges to create space and strike from a distance when he pauses to attack. Flash grenades can momentarily disrupt his assault, giving you a chance for precise shots. Stay calm, watch his patterns, and you’ll end his reign in the castle once and for all.
When you’re done with the Merchant, follow the path to the same doors you just saw Ashley and Ramon go through. Smash the two barrels on the right for pesetas, gunpowder, a velvet blue, and some handgun ammo.
Head through the doors.
After the cutscene, the fight is going to start, so you won’t have any time to prepare. There are three pairs of barrels – one to the left as soon as you start, one at the top of the stairs to the right, and one behind the wall on the landing to the left. Hit them when you can to resupply during the fight.
As soon as you get control, start shooting Ramon since he’ll stay directly ahead of you for a few seconds. He does have a glowing eyeball on his head, but that’s not really a weak point. In his mutated form, his whole head region is the weak point.
Your first task in this fight is to keep moving. If Ramon grabs you, he’ll swallow Leon whole and you’ll have to start over.
You’ll also need to keep an eye out for. spit pustules(?) on the ground. These bubbles will pop when you get too close and stun Leon for a second. If you have the ammo and a second to spare, you can also shoot them to get them out of the way. They don’t do much damage (and might even drop an item when they explode) but they’re a real inconvenience.
Beyond that, you really only have to watch for his spitting attack. He’ll spit a stream of black goo at you in a straight line. You really just need to step to the side to avoid it, and then you can use the opportunity to shoot him a bunch.
After enough damage, Ramon will fall. Run over to him and stab him in his glowing eyeball.
You have to do that a couple times (plus some more shooting) to finish the fight. Be prepared to run if you see Ramon charging at you. You can switch to your shotgun and deal some damage, but you just want to avoid getting grabbed.
When the fight is over, collect the Lip Rouge Salazar dropped, and head out to the east.
Go after Ashley // Dock
After defeating Salazar, head toward the door at the back of the chamber and pursue Ashley’s trail to the dock. Take a moment to collect any leftover resources before moving on, as you’ll need them for what lies ahead. The area leads to a small loading dock where you’ll find a boat waiting-this marks your next point of progression. Check the surroundings for crates or ammo and make sure you’re prepared before setting off.
Follow the stairs down, and smash the barrels at the bottom for pesetas and handgun ammo.
Take the elevator down. When you exit, watch for a barrel to the left with and another around the corner both with more pesetas.
Snake around the shelves and follow the hallway. At the first room, grab the Housekeeper’s Memo 1 file from the table on your right, and smash the barrel to the left for pesetas and resources (L). Take the stairs down to the dock.
Best weapons and upgrades for Ramon Salazar fight
Top Weapons for the Fight
The Broken Butterfly Magnum excels as the primary damage dealer due to its high power against Salazar’s weak eye and body, especially when fully upgraded for max damage-ideal for shortening the battle but conserve ammo for later bosses. Rifles like the CQBR Assault Rifle or Stingray are essential for tracking his fast aerial movements; upgrade fire rate and damage to maintain pressure during acid sprays.
Shotguns and Close-Range Options
Shotguns such as the Striker or Rio Bravo shine when Salazar crashes to the ground-prioritize exclusive upgrades for capacity and power to stun and shred quickly before he recovers. The Matilda handgun (if bought with 22 spinels) offers burst-fire efficiency with plentiful ammo, serving as a reliable backup.
Grenades and Utilities
Flash grenades are crucial for stunning him mid-dive or roar, buying time to shoot safely; stock several alongside regular grenades for grounded phases. Body armor protects against unavoidable hits, and knife finishers on downed Salazar save precious bullets across multiple cycles.
Ramon Salazar boss fight strategies and weak points
Ramon Salazar’s boss fight in Resident Evil 4 Remake pits Leon against a giant flying Plagas with Salazar’s body dangling inside its mouth, requiring precise aiming at weak spots amid constant acid attacks. The primary weak points are the glowing yellow eye on the main tentacle (for grounding him) and Salazar’s exposed human body/head region inside the mouth during openings, roars, or crashes-prioritize these for maximum damage.
Core Strategies
Stay mobile around the arena’s pillars and arches to block acid sprays, puddles, and dive bombs; circle the northern pillar alcove for optimal cover as it limits explosive goo pods. Use flash grenades to stun him mid-attack, then unload on the eye or body; when he crashes after 2-4 damage cycles, rush in for knife finishers to conserve ammo. Cheese tactics include throwing a Golden Chicken Egg at his body to instantly drop him (repeat for phase one win) or mine-dart arrows to the face on pro runs.
Attack Patterns
Dodge horizontal/vertical acid streams by sidestepping or crouching, shoot distant goo pods to avoid explosions, and evade his charged cannon or grab by listening for roars and fleeing pillars. In phase two, he ramps up showers and speed-prioritize post-attack windows when the mouth opens wide. On higher difficulties, body armor and upgraded fast-fire weapons turn the tide without exploits.
